Dexmedetomidine Use for Sedation in Patients Submitted to Tracheal Surgery

University of Roma La Sapienza

Status: Completed

Conditions: Postoperative Sedation

Treatments: Drug: Dexmedetomidine

Study type: Observational

Funder types: Other

Identifiers

NCT03723538

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Details and patient eligibility

About

Patients undergoing tracheal resection and reconstruction surgery are enrolled in this prospective observational pilot study to evaluate dexmedetomidine-based sedation after tracheal surgery in an Intensive Care Unit (ICU). Patients remain electively intubated with an uncuffed nasal endotracheal tube, awake and exhibit spontaneous breathing The neck was maintained in flexion through chin-to-chest sutures. Infusion of dexmedetomidine was started from a dosage of 0.7 μg kg-1 h-1 followed by dose titration to the target level of the sedation Richmond Agitation Sedation Scale, (RASS) score -1/-2 using a dose range of 0.2-1.4 μg kg-1 h-1.

Enrollment: 14 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients submitted to tracheal surgery
• elective surgery
• age ≥ 18 years

Exclusion criteria

• severe neurological disorder
• visual or hearing impairment
• acute cerebrovascular disease
• mean arterial pressure (MAP) <55 mmHg or hypotension requiring the use of inotropes/vasopressors
• heart rate (HR) <50 bpm
• second and third degree atrioventricular block (AV block) in the absence of PMK
• Sequential Organ Failure Assessment (SOFA) score <2 index
• hepatic failure
• emergency surgery
• pregnancy
• patient refusal to give consent
• inability to give consent
• age ≤18 years
• ASA score ≥ IV.