Dexmedetomidine Versus Dexamethasone With Levobupivacaine in Interscalene Block (IBBB)

Menoufia University

Status and phase: Completed; Phase 4

Conditions: Postoperative Complications; Postoperative Analgesia

Treatments: Drug: Dexmedetomidine Hydrochloride; Drug: Saline; Drug: Dexamethasone Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT03940469

Interscalene Dexmedetomidine

Details and patient eligibility

About

The investigators compared between dexamethasone and dexmedetomidine when added to levobupivacaine in the quality and duration of ultrasound-guided interscalene block during shoulder arthroscopy.

Full description

Sixty patients were enrolled and divided into three groups 20 each, Group C received 35ml levobupivacaine+2ml normal saline under ultrasound guided interscalene block. Group H received 35ml levobupivacaine+8mg dexamethasone under ultrasound guided interscalene block. Group D received 35ml levobupivacaine+100umg dexmedetomidine+1ml normal saline. The primary outcome was the postoperative pain which was assessed by Visual analog score(VAS), the secondary outcomes were the onset and duration of sensory and motor block, the total amount of analgesic requirement, and blood cortisol level.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sixty healthy patients ASA I-II
• Aged 18-60 years
• Of both sexes
• Scheduled for shoulder arthroscopy using ultrasound interscalene block were enrolled.

Exclusion criteria

• Patients with a history of any allergic reactions to levobupivacaine, dexamethasone or α2 agonists
• All patients with hypertension, cardiac, hepatic, renal or pulmonary diseases, - Patients who were under treatment by α2 agonist or antagonists
• Pregnant women
• Psychiatric patients
• Patients with a previous history or clinical evidence of central or peripheral neurological disease
• Coagulopathy or anticoagulant/antiaggregant therapy
• Contralateral phrenic nerve paresis
• Patients who have an infection at the site of the block.
• Every patient who had an anatomical or vascular abnormality in the upper extremity were excluded from this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups, including a placebo group

Control group

Placebo Comparator group

Description:

received 35ml levobupivacaine+2ml normal saline under ultrasound guided interscalene block.

Treatment:

Drug: Saline

Dexamethasone group

Active Comparator group

Description:

received 35ml levobupivacaine+8mg dexamethasone

Treatment:

Drug: Dexamethasone Injection

Dexmeteomidine group

Active Comparator group

Description:

received 35ml levobupivacaine+100umg dexmedetomidine+1ml normal saline.

Treatment:

Drug: Dexmedetomidine Hydrochloride