Dexmedetomidine Versus Ketamine on Laryngeal Microsurgery

Cairo University (CU)

Status: Completed

Conditions: Microlaryngeal Surgery

Treatments: Drug: Saline (control group); Drug: Ketamine; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT07048873

MS-502-2023

Details and patient eligibility

About

compare effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and detect side effects of dexmedetomidine and ketamine.

Full description

Microlaryngeal surgery is a common surgical procedure now a days which is associated with many complications such as postoperative pain, airway edema and persistent cough

. the study is to compare the effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and to detect side effects of dexmedetomidine and ketamine.

Enrollment: 168 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 18-70 years ASA I,II

Exclusion criteria

• CVdiseases as IHD and severe valvular disease.

  • allergy to ketamine or dexmedetomidine.
  • Patients refusal
  • Suspected difficult intubation more than 2 trials

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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168 participants in 3 patient groups

Dexmedetomidine

Experimental group

Description:

1.0mcg/kg of dexmedetomidineloading dose before induction then 0.5 mcg/kg/hr of infused till end of surgery

Treatment:

Drug: Dexmedetomidine

Ketamine

Experimental group

Description:

0.25 mg/kg/hr ketamine infused till end of surgery

Treatment:

Drug: Ketamine

Control

Active Comparator group

Description:

saline before induction infusion till end of surgery

Treatment:

Drug: Saline (control group)