Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures

National Cancer Institute, Egypt

Status: Completed

Conditions: Sedation and Analgesia

Treatments: Drug: Dexmedetomidine; Drug: Ketamine; Drug: Midazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT04597268

AP2007-50110

Details and patient eligibility

About

This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.

Full description

Comparison between using intravenous (IV) propofol combined with either IV dexmedetomidine or IV ketamine or IV midazolam; to study the effect of their combination on level of sedation and hemodynamic stability on adult patients scheduled for gastrointestinal endoscopic procedures.

Enrollment: 75 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled for gastrointestinal endoscopic procedures
• ≥ Age 18 years
• ASA I-II

Exclusion criteria

• Allergy to any of the used drugs
• impaired renal or liver functions
• hypertensive patients
• patients with cardiovascular
• cerebrovascular disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

75 participants in 3 patient groups

dexmedetomidine

Experimental group

Description:

IV dexmedetomidine

Treatment:

Drug: Dexmedetomidine

ketamine

Experimental group

Description:

IV ketamine

Treatment:

Drug: Ketamine

Midazolam

Active Comparator group

Description:

IV midazolam

Treatment:

Drug: Midazolam