Dexmedetomidine Versus Pentobarbital for Pediatric Procedural Sedation

The Washington University

Status: Withdrawn

Conditions: Sedation

Treatments: Drug: dexmedetomidine sedation protocol; Drug: pentobarbital sedation protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT00878345

colegroenersterni

Details and patient eligibility

About

The investigators believe dexmedetomidine will provide superior sedation with reduced side effects and reduced time to discharge compared with pentobarbital. The investigators have developed sedation protocols with pentobarbital and dexmedetomidine in our ambulatory procedure center. These protocols are both routinely used for sedation in our unit. The investigators propose to study these two protocols in children ages 6 months to 6 years presenting to the ambulatory procedure center for non-painful procedural sedation. The investigators will compare failure of sedation, side effect profile, recovery and discharge times between the two pharmacologic protocols.

Sex: All

Ages: 6 months to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Requiring sedation for non-painful procedures
• Normal airway per exam

Exclusion criteria

• Congenital syndromes with known difficult airways
• Known difficult airway during past anesthesia or sedation experience
• Parent/guardian refusal of participation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

1

Active Comparator group

Description:

Dexmedetomidine sedation protocol

Treatment:

Drug: dexmedetomidine sedation protocol

2

Active Comparator group

Description:

Pentobarbital sedation protocol

Treatment:

Drug: pentobarbital sedation protocol