Dexmedetomidine Versus Triamcinolone Treatment of Carpal Tunnel Syndrome

Assiut University

Status: Completed

Conditions: Carpal Tunnel Syndrome; Chronic Pain

Treatments: Drug: Dexmedetomidine; Drug: Triamcinolone

Study type: Interventional

Funder types: Other

Identifiers

NCT04961281

IRB0002021

Details and patient eligibility

About

Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS.

Full description

Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS.

In case of failed conservative oral therapey, local hydro-dessction of the median nerve can be done with saline alone. local anethetics, steroids, hyalase,and ozone have been utilized to augment the symptoms reliefe.

Dexmeditomidine (DEX) has been studied as adjuvant for nerve block to aumnet the pain reliefe. Recently, it has been discovered that DEX can offer some antinflammatory effects when injected in the perineural area. Upon such discovery, the goal of this study has been built.

Enrollment: 60 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients
• complaining of carpal tunnel syndrome of 3 month duration or more
• diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study

Exclusion criteria

• patient refusal
• infection at the site of intervention
• allergy to utilized drugs
• diabetic
• previous surgery in the site of injection
• previous injection in the targeted site within the last year

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Dexmeditomidine group

Active Comparator group

Description:

injection of 1 microgram/kg dexmeditomidine + 10 cc saline injection nearby median nerve as hydro-dissection

Treatment:

Drug: Dexmedetomidine

triamcinolone group

Active Comparator group

Description:

injection of 40 mg triamcinolone + 10 cc saline injection nearby median nerve as hydro-dissection

Treatment:

Drug: Triamcinolone