Dexmedetomidine vs Control on Attenuation Hemodynamic Response to Noxious Stimuli in CABG Surgical Patients

Sawanpracharak hospital

Status: Not yet enrolling

Conditions: CABG

Treatments: Drug: Dexmedetomidine; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT06238011

padetboonmark

sawanpracharakhospital (Registry Identifier)

Details and patient eligibility

About

Aim to study efficacy of dexmedetomidine to attenuate hemodynamic response to intubation, skin incision, sternotomy and aortic cannulation

Full description

A randomized controlled trial was conduct between January2024 and March2024 at Sawanpracharak hospital, Thailand. Of 60 patients undergoing elective coronary artery bypass graft, 30 were assigned to group dexmedetomidine and 30 to group control. Dexmedetomidine prepared by anesthetist nurse in concentration 0.1 microgram/kg/ml total volume 50 ml. loading dose 60 ml/hour for 10 minutes before induction of anesthesia then 5ml/hour until the patient on cardiopulmonary bypass (loading dose 1 microgram/kg for 10 minutes then 0.5 microgram/kg/hour). Group control receive normal saline 60ml/hour for 10minutes then 5 ml/hour

Enrollment: 60 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients schedule for CABG
• American Society of Anesthesiologist (ASA) class II-III

Exclusion criteria

• anticipated difficult intubation
• body mass index> 30 kg/m2
• Ejection Fraction < 40%
• left main coronary artery occlusion >50%
• left bundle branch block
• severe valvular heart disease
• severe pulmonary, renal, hepatic disease
• neurologic disease
• preoperative medication with methyldopa or clonidine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 2 patient groups, including a placebo group

Dexmedetomidine

Active Comparator group

Description:

Patient in this arm will receive dexmedetomidine loading 60ml/hour before induction of anesthesia then 5ml/hour until the patient on cardiopulmonary bypass

Treatment:

Drug: Dexmedetomidine

Normal Saline

Placebo Comparator group

Description:

Patient in this arm will receive normal saline loading 60ml/hour before induction of anesthesia then 5ml/hour until the patient on cardiopulmonary artery bypass

Treatment:

Drug: Normal saline