Dexmedetomidine vs Control on Attenuation Hemodynamic Response to Noxious Stimuli in CABG Surgical Patients

S

Sawanpracharak hospital

Status

Not yet enrolling

Conditions

CABG

Treatments

Drug: Dexmedetomidine
Drug: Normal saline

Study type

Interventional

Funder types

Other

Identifiers

NCT06238011
padetboonmark
sawanpracharakhospital (Registry Identifier)

Details and patient eligibility

About

Aim to study efficacy of dexmedetomidine to attenuate hemodynamic response to intubation, skin incision, sternotomy and aortic cannulation

Full description

A randomized controlled trial was conduct between January2024 and March2024 at Sawanpracharak hospital, Thailand. Of 60 patients undergoing elective coronary artery bypass graft, 30 were assigned to group dexmedetomidine and 30 to group control. Dexmedetomidine prepared by anesthetist nurse in concentration 0.1 microgram/kg/ml total volume 50 ml. loading dose 60 ml/hour for 10 minutes before induction of anesthesia then 5ml/hour until the patient on cardiopulmonary bypass (loading dose 1 microgram/kg for 10 minutes then 0.5 microgram/kg/hour). Group control receive normal saline 60ml/hour for 10minutes then 5 ml/hour

Enrollment

60 estimated patients

Sex

All

Ages

40 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients schedule for CABG
  • American Society of Anesthesiologist (ASA) class II-III

Exclusion criteria

  • anticipated difficult intubation
  • body mass index> 30 kg/m2
  • Ejection Fraction < 40%
  • left main coronary artery occlusion >50%
  • left bundle branch block
  • severe valvular heart disease
  • severe pulmonary, renal, hepatic disease
  • neurologic disease
  • preoperative medication with methyldopa or clonidine

Trial design

60 participants in 2 patient groups, including a placebo group

Dexmedetomidine
Active Comparator group
Description:
Patient in this arm will receive dexmedetomidine loading 60ml/hour before induction of anesthesia then 5ml/hour until the patient on cardiopulmonary bypass
Treatment:
Drug: Dexmedetomidine
Normal Saline
Placebo Comparator group
Description:
Patient in this arm will receive normal saline loading 60ml/hour before induction of anesthesia then 5ml/hour until the patient on cardiopulmonary artery bypass
Treatment:
Drug: Normal saline

Trial contacts and locations

0

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Central trial contact

Padet Boonmark, MD

Data sourced from clinicaltrials.gov

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