Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries

National Cancer Institute, Egypt

Status: Completed

Conditions: Analgesia

Treatments: Drug: Intravenous morphine; Procedure: Bilateral Erector spinae plane block with dexamethasone; Procedure: Bilateral Erector spinae plane block with dexmedetomidine; Procedure: Bilevel Erector spinae plane block

Study type: Interventional

Funder types: Other

Identifiers

NCT05591417

AP2207-30110

Details and patient eligibility

About

High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain. Several techniques are adopted to control perioperative pain, these techniques include drugs as opioids and adjuvants as well as regional blocks. Erector spinae plane block is a regional technique that is used efficiently to control perioperative pain during and following breast cancer surgeries.

Full description

High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain. Several techniques are adopted to control perioperative pain, these techniques include drugs as opioids and adjuvants as well as regional blocks. Erector spinae plane block is a regional technique that is used efficiently to control perioperative pain during and following breast cancer surgeries. Adding adjuvant drugs as dexmedetomidine or dexamethasone can augment the local anesthetic effect for the regional block used.

Enrollment: 68 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female patients scheduled for Modified Radical Mastectomy MRM
• Physical status ASA II, III.
• Age (18-65) years
• Body mass index (BMI): (20-35) kg/m2.

Exclusion criteria

• Patient refusal.
• Age <18 years or >65 years.
• BMI <20 kg/m2 and >35 kg/m2.
• Known sensitivity or contraindication to drug used in the study (local anaesthetics, opioids, dexamethasone, dexmedetomedine).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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68 participants in 4 patient groups

Intravenous morphine

Active Comparator group

Description:

Patients will receive intravenous morphine 0.1 mg/kg

Treatment:

Drug: Intravenous morphine

Bilevel erector spinae plane block

Experimental group

Description:

Patients will receive erector spinae plane block at 2 levels

Treatment:

Procedure: Bilevel Erector spinae plane block

Bilevel erector spinae plane block with dexamethasone

Experimental group

Description:

Patients will receive erector spinae plane block at 2 levels with dexamethasone

Treatment:

Procedure: Bilateral Erector spinae plane block with dexamethasone

Bilevel erector spinae plane block with dexmedetomidine

Experimental group

Description:

Patients will receive erector spinae plane block at 2 levels with dexmedetomidine

Treatment:

Procedure: Bilateral Erector spinae plane block with dexmedetomidine