Dexmedetomidine vs. Propofol for Cataract Surgery

Cooper University Health Care

Status and phase: Completed; Phase 4

Conditions: Cataract

Treatments: Drug: Propofol; Drug: dexmedetomidine; Drug: Dexemedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT00786370

RP 08-045

Details and patient eligibility

About

The use of dexmedetomidine in cataract surgery is still limited and to date only one study has examined anesthetic technique in this patient population. This pilot study will therefore compare the use of dexmedetomidine and propofol in subjects undergoing cataract surgery. The primary endpoint will be based on simple cardiorespiratory measures often associated with complications from sedation as well as assessment of the achieved sedation by the attending anesthesiologist and surgeon.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Normal renal function
2. No chronic use of narcotics
3. ASA PS1-3
4. Males or females age 18 or older

Exclusion criteria

1. Liver disease (Child Pugh classification 1-3)
2. History of chronic use of sedatives, narcotics, alcohol or illicit drugs or allergy to any the study medications
3. History of 1st and 2nd degree heart block (not paced)
4. Any patient with EF < 30%
5. Patients with active seizure history
6. Pregnant patients (women of child bearing potential will have a preoperative pregnancy test as is standard of practice)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups

Propofol

Active Comparator group

Treatment:

Drug: Propofol

Dexmedetomidine

Experimental group

Treatment:

Drug: Dexemedetomidine

Drug: dexmedetomidine