Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.

The First Affiliated Hospital of Anhui Medical University

Status: Completed

Conditions: Local Anesthesia; Anesthesia

Treatments: Drug: dexmedetomidine; Drug: propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02793986

PJ2015-07-12

Details and patient eligibility

About

With blocks of lumbar and lumbar plexus, we can reduce the intravenous anesthetics usage. To offer an satisfied surgery process for patients, a proper sedation is necessary. So in this study, we want to investigate the influence of two different sedative drugs on outcomes of patients received hip replacement surgery .

Enrollment: 296 patients

Sex: All

Ages: 65 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 65 years or older and undergoing hip fracture repair

Exclusion criteria

• Patients with severe cognitive impairment (MMSE score, <15)
• Preoperative delirium as determined by Confusion Assessment Method
• Contraindications to local anesthesia
• Prior hip surgery
• Mental or language barriers that would preclude data collection
• Severe congestive heart failure (NewYork Heart Association class IV)
• Severe chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease guidelines, stage III-IV)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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296 participants in 2 patient groups

dexmedetomidine sedation

Experimental group

Description:

Patients received local anesthesia, in this arm, the sedation of patients was achieved with a bolus of dexmedetomidine at 1.0 μg/kg (over a period of 15 to 20 min) and followed by an infusion of dexmedetomidine at 0.2-0.7 μg/kg/h.

Treatment:

Drug: dexmedetomidine

propofol sedation

Experimental group

Description:

Patients received local anesthesia, in this arm, the sedation of patients was achieved with a target-controlled infusion (TCI) of propofol, and the effect site concentration was set to 0.8-1.0μg/ml.

Treatment:

Drug: propofol