Dexmetomedine as an Adjuvant to Bupivacaine in Ultrasound Guided PECS Block

Menoufia University

Status: Completed

Conditions: Post Operative Pain

Treatments: Procedure: Pecs block

Study type: Interventional

Funder types: Other

Identifiers

NCT05717114

1/2023,ANET2-1

Details and patient eligibility

About

Regional anesthesia is an essential component of anesthesia and analgesia. It has many advantages, it decreases pain post operatively, improves patient outcome and allow early recovery and ambulation Post-operative pain following breast surgery results from injured muscles and nerves, management of acute post operative pain is a consistent factor for better outcome and patient satisfaction

Full description

All patients will be monitored by standard intraoperative monitoring that includes continuous electrocardiography (ECG), capnography, pulse oximetry, and non invasive blood pressure.

Induction of general anesthesia will be done by propofol 1.5-2 mg/kg and fentanyl 3µg/kg.

Tracheal intubation will be facilitated by administration of rocuronium 0.8 mg/kg. Anesthesia will be maintained with isoflurane 1MAC (Pecs block):the block will be performed with the patients in the supine position.The infraclavicular and axillary regions will be cleaned with antiseptic solution. the in plane technique will be used from proximal and medial to distal and lateral in an oblique manner at dermatome level T2 and T3.The puncture site was infiltrated with 2%lidocaine and once the structures is identified with Ultrasound

Enrollment: 96 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adult patients
• aged 18-60years old
• ASA class 1 to 3
• scheduled for elective modified radical mastectomy

Exclusion criteria

• patients refusal,
• coagulopathies
• concurrent anticoagulant therapy
• allergy to local anaesthetics
• infection at puncture site

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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96 participants in 3 patient groups, including a placebo group

Group I

Placebo Comparator group

Description:

received plan bupivacaine1ml/Kg

Treatment:

Procedure: Pecs block

Group II

Active Comparator group

Description:

received plain bupivacaine 1ml/Kg plus dexmetomedine0.5 µg/Kg

Treatment:

Procedure: Pecs block

GroupIII

Active Comparator group

Description:

received plain bupivacaine 1ml/Kg plus dexmetomedine1µg/Kg

Treatment:

Procedure: Pecs block