Dextrose Effect on Postoperative Nausea and Vomiting (PONV)

Assiut University

Status: Completed

Conditions: Postoperative Nausea and Vomiting

Treatments: Other: Saline placebo; Other: Dextrose 10%; Other: Dextrose 5% in water

Study type: Interventional

Funder types: Other

Identifiers

NCT04726436

Dextrose PONV

Details and patient eligibility

About

The aim of this study to assess which time and dose of dextrose solution more effective in decreasing postoperative nausea and vomiting.

Full description

All patients signed informed consent after excluding patients not candidate for the study.patients were divided to three groups, taking either 0.9% saline as control group(group C), dextrose 5%(group D5) or dextrose 10%(group D10).

Enrollment: 120 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female non-smokers adults (age 18-65 years)
• ASA I-II who were listed for elective surgery under general anesthesia (surgery which is risk for PONV).

Exclusion criteria

• Severe hypertension
• Coagulopathy
• Significant hepatic or renal disease
• Diabetes mellitus or abnormal blood glucose on the morning of surgery
• Withdrawal of consent
• Severe intraoperative hypotension requiring large volume intravascular fluid treatment
• Protocol violations including nitrous oxide administration.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups, including a placebo group

Dextrose 5%

Experimental group

Description:

100 mL/ hour of dextrose 5% were given starting 1 hour before operation and continue till approximately middle of surgery by communicating with surgeon to assess the timing and dosing of dextrose solution effect on PONV.

Treatment:

Other: Dextrose 5% in water

Dextrose 10%

Experimental group

Description:

100 mL/ hour of dextrose 10% were given starting 1 hour before operation and continue till approximately middle of surgery by communicating with surgeon

Treatment:

Other: Dextrose 10%

Saline placebo

Placebo Comparator group

Description:

100 mL/ hour of normal saline were given starting 1 hour before operation and continue till approximately middle of surgery by communicating with surgeon

Treatment:

Other: Saline placebo