DFDBA and Xenograft (Cerabone)TM With Decortication in Intrabony Defects

Krishnadevaraya College of Dental Sciences & Hospital

Status and phase: Completed; Phase 4

Conditions: Periodontal Intrabony Defects

Treatments: Procedure: Decortication + bone grafts

Study type: Interventional

Funder types: Other

Identifiers

NCT02949557

02_D012_54500

Details and patient eligibility

About

DFDBA is an allograft that possesses osteoconductive and osteoinductive properties. It has the potential for osteoinduction due to increased expression of bone morphogenetic protein (BMP).Cerabone™ has shown maximum resemblance to human bone with the potential to reconstruct bone defects. Decortication is performed as a part of guided bone regeneration (GBR) procedure as it enhances the healing process.Therefore a combination of decortication and bone graft when applied in periodontal intrabony defect would enhance the regeneration of periodontium.

Full description

There have been great strides in the management of periodontal intrabony defects, especially with the use of bone graft materials. It is necessary to choose the most appropriate material and procedure in order to obtain the desired regeneration. Among the bone grafts, Demineralised freezed dried bone allograft (DFDBA) and xenografts have shown good results in the management of intrabony defects. Recently, a novel bovine xenograft i.e., Cerabone™ has shown maximum resemblance to human bone with the potential to reconstruct bone defects. Decortication or intramarrow penetration of the bone has shown favourable results in guided bone regeneration procedures. So the goal of the present study was to check the efficacy of decortication with decalcified freeze dried bone allograft (DFDBA) and Cerabone™ bone grafts and to compare the response between the bonegrafts placed following decortication using RVG and CBCT, in intrabony defect.

The combination of decortication with bone grafts i.e., DFDBA and (Cerabone)TM can be an added advantage in the treatment of intrabony defects. To the best of the investigators knowledge no clinical trial reports this combination therapy in scientific literature. There is need for further research in this area.

Enrollment: 10 patients

Sex: All

Ages: 25 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age group 25-45 years
• Moderate periodontitis with pocket probing depth more than 5 mm
• Bilaterally similiar intrabony defects
• systemically healthy patients
• Good compliance

Exclusion criteria

• medically compromised
• Pregnant and lactating women
• Smoking
• teeth with mobility and furcation involvement

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

10 participants in 2 patient groups

Decortication +DFDBA

Active Comparator group

Description:

After phase 1 therapy patients were assigned for decortication+ DFDBA group. Mucoperiosteal flaps were reflected. After open flap debridement, decortication was performed and DFDBA graft was placed in the treatment of intrabony defects.

Treatment:

Procedure: Decortication + bone grafts

Decortication+ Xenograft (Cerabone)TM

Active Comparator group

Description:

After phase 1 therapy patients were assigned for decortication+ xenograft (Cerabone)TM group. Mucoperiosteal flaps were reflected. After open flap debridement, decortication was performed and DFDBA graft was placed in the treatment of intrabony defects.

Treatment:

Procedure: Decortication + bone grafts