DHA Supplementation and Pregnancy Outcome

Colorado State University (CSU)

Status: Completed

Conditions: Pregnancy

Treatments: Dietary Supplement: 300 mg DHA; Dietary Supplement: 600 mg DHA; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT02219399

00186H

Details and patient eligibility

About

Supplementation with DHA during pregnancy will increase gestational length and improve cognitive development.

Full description

This was a trial of supplementation with DHA during pregnancy to increase gestational length. Subjects were provided with 300 mg, 600 mg or placebo (olive oil) in a randomized design from week 24-26 of pregnancy until delivery. Gestational age, birth weight and birth length data were collected and infants growth at 2 and 4 months and cognitive development at 4 months and 1 year were measured.

Enrollment: 871 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• singleton pregnancy
• 18 years of age or older

Exclusion criteria

• cervical incompetence
• presence of cervical cerclage
• placenta previa
• intrauterine infection
• known substance abuse
• multiple fetuses
• current pre-eclampsia
• preexisting diabetes

Trial design

871 participants in 3 patient groups, including a placebo group

300 mg DHA

Experimental group

Description:

300 mg DHA

Treatment:

Dietary Supplement: 300 mg DHA

Placebo

Placebo Comparator group

Description:

olive oil or high oleic acid sunflower oil placebo

Treatment:

Dietary Supplement: Placebo

600 mg DHA

Experimental group

Description:

600 mg DHA

Treatment:

Dietary Supplement: 600 mg DHA