Diagnosic and Pronostic Values of Kappa and Lambda Free Light Chains in Central Nervous System Inflammatory Diseases

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Multiple Sclerosis; Central Nervous System Diseases

Treatments: Other: Biological collection

Study type: Observational

Funder types: Other

Identifiers

NCT05088473

21Neuro01

Details and patient eligibility

About

Numerous studies have shown the diagnostic interest of cerebrospinal fluid kappa free light chains and kappa index in multiple sclerosis. However, large cohort studies are lacking and little is known about the correlation between kappa and lambda indexes and multiple sclerosis evidence disease activity. Therefore, this study plan to validate the kappa and lambda free light chains and indexes as diagnostic biomarker in multiple sclerosis and to correlate the concentration of kappa and lambda free light chains with clinical and radiological activity in a large cohort of patients.

Enrollment: 1,500 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting with symptoms evocative of CNS involvement for who serum and cerebrospinal fluid kappa free light chains and kappa index are available

Exclusion criteria

• Infectious CNS disease
• Tumor CNS disease
• Active CNS bleeding
• Monoclonal gammapathy
• Severe chronic renal failure (glomerular filtration rate <30 ml/mn)

Trial design

1,500 participants in 4 patient groups

Mutliple sclerosis

Treatment:

Other: Biological collection

CIS/RIS

Treatment:

Other: Biological collection

Other CNS inflammatory diseases

Treatment:

Other: Biological collection

Non inflammatory CNS diseases

Treatment:

Other: Biological collection