Diagnosing of Acute Tuberculosis (SwEaTB)

University Hospital Basel

Status: Completed

Conditions: Tuberculosis

Treatments: Diagnostic Test: analysis of sweat and serum samples for protein markers

Study type: Observational

Funder types: Other

Identifiers

NCT03667742

2017-01455 me17Eckstein2;

Details and patient eligibility

About

Sweat proteins are analysed to investigate differences in protein markers in patients with acute tuberculosis and other pulmonary diseases (pneumonia, Bronchitis, chronic obstructive pulmonary disease (COPD)) and healthy individuals. Differences in sweat protein markers in patients with positive and negative tuberculosis Enzyme-linked-immuno-Spot (EliSpot) are investigated.

Differences in sweat protein markers in the course of treatment in patients receiving tuberculostatic therapy are investigated.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Ability to understand the purpose of the study, provide signed and dated informed consent by patient or his/her legal representative
• In-patients with acute tuberculosis, suspected tuberculosis or other pulmonary diseases (pneumonia, Bronchitis, COPD)

Inclusion Criteria Healthy Donors:

• negative for Quantiferon- TB Gold Plus Test or ELISpot

Exclusion criteria

• Initiation of tuberculostatic therapy before baseline
• Initiation of antibiotic therapy in patients with other pulmonary diseases > 6 hours before baseline