Diagnosing Pulmonary Aspergillosis in Patients With Hematological Malignancies: A Multicentre Prospective Evaluation of an Aspergillus PCR Assay and a Galactomannan ELISA in Bronchoalveolar Lavage Samples

Heidelberg University

Status: Completed

Conditions: Invasive Aspergillosis

Study type: Observational

Funder types: Other

Identifiers

NCT01430663

AGIHO BAL GM PCR 2007

Details and patient eligibility

About

Diagnosing invasive pulmonary aspergillosis (IPA) remains a challenge in patients (pts) with hematological malignancies. The clinical significance of testing bronchoalveolar lavage (BAL) samples both with polymerase chain reaction (PCR) and Aspergillus galactomannan (GM) ELISA is unclear, and the BAL cutoff for GM has not been clearly defined yet. Using a validated nested PCR assay and a GM ELISA, we prospectively examine BAL samples from hematological patients at high risk of PA.

Enrollment: 87 patients

Sex: All

Ages: 5 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hematological patients with lung infiltrates at high risk for invasive aspergillosis

Exclusion criteria

• patients without informed consent

Trial design

87 participants in 2 patient groups

Hematological patients with proven or probable aspergillosis

Hematological patients with possible aspergillosis