Diagnosing Respiratory Disease in Children Using Cough Sounds 2 (SMARTCOUGH-C-2)

ResApp Health

Status: Completed

Conditions: Lower Respiratory Disease; Bronchiolitis; Asthma Exacerbation; Reactive Airway Disease; Croup; Viral Lower Respiratory Tract Infections; Pneumonia; Upper Respiratory Disease

Treatments: Device: Recordings of Infants and Children's Cough Sounds

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03392363

17001

Details and patient eligibility

About

The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in the diagnosis of childhood acute respiratory disease, including pneumonia, bronchiolitis, asthma/reactive airways disease, croup, lower respiratory tract disease (LRTD), viral lower respiratory tract infection (vLRTI), and upper respiratory tract disease (URTD).

Enrollment: 1,470 patients

Sex: All

Ages: 29 days to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infant or child aged greater than 29 days up to and including their 12th birthday (infant and children pediatric subgroups as defined in Guidance for Industry and Food and Drug Administration Staff: Premarket Assessment of Pediatric Medical Devices dated March 24, 2014)
• Presenting to the study site (an outpatient facility, an urgent care center, an Emergency Department, or inpatient ward within 24 hours of admission) with current signs or symptoms of respiratory disease including cough, wheezing, stridor, chest in-drawing/retractions, difficulty breathing, fast breathing, nasal congestion/rhinorrhea, abnormal lung sounds on exam or cyanosis/hypoxemia.
• Onset of symptoms within past 14 days
• Outpatient or inpatient within 24 hours of admission
• Coughing spontaneously or able to cough voluntarily

Exclusion criteria

• Lack of a signed consent form from parent or legal guardian
• Lack of signed assent form for children aged 7 years or older who, in the opinion of the investigator, is able to provide assent based on their age, maturity or psychological state.
• Need for mechanical ventilatory support ((including invasive, CPAP, or BiPAP)) or high flow nasal cannula
• History of structural airways abnormalities, tracheobronchomalacia, or vocal cord abnormalities (e.g. laryngomalacia, tracheomalacia, or bronchomalacia)
• Any medical contraindication to voluntary cough, including the following (only enroll if coughing spontaneously): severe respiratory distress, history of pneumothorax, eye/chest/abdominal surgery in past 3 months, hemoptysis in the past month
• Too medically unstable to participate in study per treating clinician
• Subject previously enrolled in SMARTCOUGH-C-2 study
• Tracheostomy present or tube placed