Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque

Aristotle University Of Thessaloniki

Status: Completed

Conditions: Stroke; Carotid Atherosclerosis; Type 2 Diabetes; Metabolic Syndrome

Treatments: Drug: rimonabant; Drug: metformin; Drug: atorvastatin; Drug: rosiglitazone

Study type: Interventional

Funder types: Other

Identifiers

NCT00636766

887/2005

Details and patient eligibility

About

The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor antagonists on atherosclerotic plaque texture in patients with cardiovascular risk and animals prone to atherosclerosis.

Enrollment: 300 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Carotid atherosclerosis
• Femoral atherosclerosis
• Cardiovascular risk

Exclusion criteria

• Heart failure
• Renal disease
• Liver disease
• Life-threatening diseases

Trial design

300 participants in 1 patient group

1

Experimental group

Treatment:

Drug: rimonabant

Drug: atorvastatin

Drug: metformin

Drug: rosiglitazone