Diagnosis, Incidence and Consequences of PACU-Delirium (PADE-DIC)

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Elderly Patient; Cognitive Decline; Postoperative Delirium

Study type: Observational

Funder types: Other

Identifiers

NCT04978870

2020-10331-BO-ff

Details and patient eligibility

About

This study aims to

1. determine sensitivity and specificity of the Confusion Assessment Method for Postanesthesia Care Unit (CAM-PACU)
2. examine the effect of postanesthesia care unit delirium (PACU delirium) on the emergence of later onset postoperative delirium (POD) as well as cognitive recovery until one month postoperatively

Enrollment: 450 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• planned surgery in the near future
• surgery time at least 60min

Exclusion criteria

• intracranial surgery
• expected postoperative transfer to ICU and stay exceeding 24h
• length of postoperative stay in hospital below 24h
• insufficient German language skills
• current alcohol or drug misuse
• manifest mental illness

Trial design

450 participants in 2 patient groups

1 - Validation

Description:

Group 1 will be screened for delirium during the PACU stay using the CAM-PACU. Delirium criteria as defined by ICD-10 will be assessed in comparison. A subgroup of patients will receive an additional delirium screening using the CAM-PACU. This screening will be performed by another operator blinded for the results from the initial delirium screening.

2 - Cognition

Description:

Group 2 will be screened for delirium during the PACU stay using the CAM-PACU. Delirium criteria as defined by ICD-10 will be assessed in comparison. This group will undergo additional assessment of preoperative and postoperative cognitive function as well as a POD screening using the 3D-CAM starting at postoperative day 1 until discharge from hospital but no longer than postoperative day 5.