Diagnosis of Bladder Pain Syndrome / Interstitial Cystitis

Cantonal Hospital, Frauenfeld

Status: Completed

Conditions: Interstitial Cystitis; Bladder Pain Syndrome; Overactive Bladder

Treatments: Procedure: biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT03023241

9900.013 BPS/IC study

KEKTGOV2010/01 (Other Identifier)

Details and patient eligibility

About

To identify new, simple and reliable biomarkers for bladder pain syndrome/interstitial cystitis (BPS/IC) for diagnosis of this disease.

Full description

Collection and analyses of bladder biopsies, bladder washings, blood and urine samples of patients with bladder pain syndrome/interstitial cystitis (BPS/IC), overactive bladder syndrome (OAB) and bladder-healthy controls. Analyses include ELISA, RT-qPCR, DNA sequencing, and immunohistochemistry techniques. Differences between patient groups are statistically evaluated.

Enrollment: 300 patients

Sex: Female

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient with diagnosed BPS/IC, OAB or healthy controls
• included healthy controls must have another pelvic surgery planned (e.g. hysterectomy)
• being able to act and judge

Exclusion criteria

• unstable endocrinological situation
• severe illness

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

300 participants in 1 patient group

all study patients

Experimental group

Description:

Same intervention for all subjects: anamnesis, questionnaires and biological samples (bladder biopsy, bladder washing, blood and urine) are collected at one single visit.

Treatment:

Procedure: biopsy