Diagnosis of Bone Metabolism in Patients With Inexplicable Lower Back Pain

Rigshospitalet

Status: Active, not recruiting

Conditions: Lower Back Pain Chronic

Treatments: Diagnostic Test: [18F]NaF PET/CT scan

Study type: Observational

Funder types: Other

Identifiers

NCT05801848

H-19039428

Details and patient eligibility

About

The main goal of this study is to determine if static or dynamic [18F]NaF PET/CT (positron emitting tomography) can identify the source of lower backpain in at least 20% of the patients experiencing lower backpain, yet could not be diagnosed from MRI or CT scans.

Full description

Patients with chronic lower backpain are routinely scanned with MR and/or CT to diagnos the source of pain. Larger studies have reported that approximately 20% of patients are given a certain diagnosis from the scans and in the majority of cases the source of the pain is not determined. The use of [18F]NaF PET/CT to map bone perfusion and metabolism is a routine clinical scan that can potentially identify the source of lower backpain in MRI and CT negative patients.

Hypothesis: That [18F]NaF PET/CT bone metabolism and bone perfusion images would contain information that allow the correct diagnosis in at least 20% of patients where MRI and CT images did not reveal pathology.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Over 18 years
• Chronic lower back pain with no concrete diagnosis after MRI and/or CT
• Under the the care of Rigshospitalets centre for Rheumatology and Spine Disease

Exclusion criteria

• previous operation in the lower back area
• Known inflammatory related illness or progressive rheumatism

Trial design

50 participants in 2 patient groups

Chronic lower back pain patients

Description:

Patients with chronic lower back pain where the source could not be identified on MRI scans

Treatment:

Diagnostic Test: [18F]NaF PET/CT scan

Age matched healthy controls

Description:

Healthy individuals without any previously known pain or intervention on lower back

Treatment:

Diagnostic Test: [18F]NaF PET/CT scan