Diagnosis of Depressive Disorder Malinger Using the Niacin Skin Response Test (NSRT)

Air Force Military Medical University of People's Liberation Army

Status: Not yet enrolling

Conditions: Malingering; Depressive Disorder

Treatments: Diagnostic Test: Niacin skin reaction test

Study type: Observational

Funder types: Other

Identifiers

NCT06382532

AFMMUChina_NSRT

Details and patient eligibility

About

This study will explore the specific response characteristics of the niacin skin response test in the population with depressive disorder malinger. The investigators expect that depressive disorder malinger can be discriminated by the niacin skin reaction test.

Full description

Depressive disorder malingers are prevalent, and it is difficult to recognize. As an objective and scientific endophenotype of depressive disorders, the blunted features in NSRT are determined by genetic factors and are not influenced by the mental state of individual subjects at a particular moment, which can provide a reliable retrospective biological index for the determination of mental and psychological state of depressive disorder malinger.

This study will explore the specific response characteristics of the niacin skin response test in the population with depressive disorder malinger, explore the application prospects of this technology in the field of biological identification, and establish a high-specificity biological diagnostic model for depressive disorder malinger and validate and optimize it, so as to provide a biological basis for the accurate and efficient identification of depressive disorder malingers using objective indexes in the process of clinical practice.

Enrollment: 410 estimated patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Depressive Disorder Malinger Group:

1. Clinical complaints meeting DSM-5 criteria for the diagnosis of depressive disorder;
2. Patients with first-episode fraudulent disease who meet the DSM-5 criteria for the diagnosis of Z76.5;
3. Age 18-60 years, Males;
4. Voluntary informed consent.

Depressive Disorder Group:

1. Patients with a first depressive disorder meeting DSM-5 criteria;
2. Age 18-60 years, Males;
3. Voluntary informed consent.

Healthy control group:

1. M.I.N.I scale rating without any mental disorder;
2. PHQ-9 <5 ;
3. No history of mental illness, no family genetic history;
4. Age 18-60 years old, Males;
5. Voluntary informed consent form.

Exclusion criteria

1. History of traumatic brain injury;
2. Continuous use of non-steroidal anti-inflammatory drugs within the last two weeks.

Trial design

410 participants in 3 patient groups

Healthy control group

Description:

1. M.I.N.I scale rating without any mental disorder; 2. Patient Health Questionnaire (PHQ-9) \< 5; 3. No history of mental illness, no family genetic history; 4. Age 18-60 years old, Males; 5. Voluntary informed consent form.

Treatment:

Diagnostic Test: Niacin skin reaction test

Depressive disorder group

Description:

1. Patients with a first depressive disorder meeting DSM-5 criteria; 2. Age 18-60 years, Males; 3. Voluntary informed consent.

Treatment:

Diagnostic Test: Niacin skin reaction test

Depressive disorder malinger group

Description:

1. Clinical complaints meeting Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for the diagnosis of depressive disorder; 2. Patients with first-episode fraudulent disease who meet the DSM-5 criteria for the diagnosis of Z76.5; 3. Age 18-60 years, Males; 4. Voluntary informed consent.

Treatment:

Diagnostic Test: Niacin skin reaction test