Diagnosis of MGRS in Patients With Paraproteinemias: Clinical, Anatomopathological and Pathophysiological Study (MGRS-CAPS)

Academia Nacional de Medicina

Status: Unknown

Conditions: Monoclonal Gammopathy of Renal Significance

Study type: Observational

Funder types: Other

Identifiers

NCT03629561

T.I. N° 12702/18/H

Details and patient eligibility

About

This is the first prospective study which evaluate patients with small B-cell clones to diagnose monoclonal gammopathy of renal significance (MGRS) and characterize it clinically, anatomopathologically and pathophysiologically taking int account a geriatric approach.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Paraproteinemias

Exclusion criteria

• Multiple Myeloma
• Waldenstrom Macroglobulinemia
• Chronic Lymphocytic Leukemia
• Malignant Lymphoma
• Monoclonal gammopathy of unknown significance (MGUS) secondary to Infections
• MGUS secondary to Autoimmune Diseases
• Uncompleted hematological evaluation
• Renal tumor except for cysts Bosniak type I/II
• Other malignant neoplasia
• Unresolved obstructive uropathy
• Patients with only one kidney except for renal transplant
• Co-morbidities which would limit the ability to receive aggressive therapeutic intervention
• Fragile old people
• Pregnancy
• Prison
• Impatient in psychiatric institutions.