Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension

National Institutes of Health (NIH)

Status: Completed

Conditions: Hypertension; Cardiovascular Diseases; Heart Diseases

Study type: Observational

Funder types: NIH

Identifiers

NCT00005394

R01HL053693 (U.S. NIH Grant/Contract)

4300

Details and patient eligibility

About

To identify and study a large cohort of glucocorticoid remediable aldosteronism (GRA) patients.

Full description

DESIGN NARRATIVE:

The spectrum of the severity and the natural history of the disorder was characterized. Modifying environmental and genetic factors important in regulation of blood pressure were determined. Also, renal physiology was studied in GRA patients to determine how these patients escaped hypokalemia in spite of mineralocorticoid excess. There were four specific aims including: 1) to determine the natural history and prevalence of GRA in various hypertensive populations, 2) to characterize the magnitude of effect imparted on blood pressure by inheritance of GRA and the sources of variation in phenotype expression of the hypertension, 3) to investigate the renal and hormonal mechanisms regulating potassium conservation and loss in GRA, and 4) to characterize the disequilibrium of GRA with Irish and Scottish descent and specific alleles of the aldosterone synthase gene.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Sex: All

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria