Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions

Fayoum University

Status: Completed

Conditions: Potentially Malignant Lesions; Oral Lichen Planus; Leukoplakia, Oral

Treatments: Diagnostic Test: Real-time Polymerase Chain Reaction technique

Study type: Observational

Funder types: Other

Identifiers

NCT05730855

1152014

Details and patient eligibility

About

The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.

Enrollment: 45 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• participants will be divided into 3 groups:

Group I: patients suffering from oral lichen planus Group II: patients suffering from leukoplakia Group III: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions.

Exclusion criteria

• Subjects taking any drugs inducing any changes that could affect the salivary flow.
• Pregnant females.
• Subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling.
• Patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.

Trial design

45 participants in 3 patient groups

Oral Lichen Planus

Treatment:

Diagnostic Test: Real-time Polymerase Chain Reaction technique

Leukoplakia

Treatment:

Diagnostic Test: Real-time Polymerase Chain Reaction technique

Healthy control

Treatment:

Diagnostic Test: Real-time Polymerase Chain Reaction technique