Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing (EFFU-ASP)

Heidelberg University

Status: Unknown

Conditions: Invasive Aspergillosis; Pleural Effusion; Immunosuppression

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02104479

EFFU-ASP 2014

Details and patient eligibility

About

Diagnostic accuracy of biomarker testing (galactomannan (GM), (1

Full description

A multicentre, open, prospective diagnostic study on the diagnostic accuracy of biomarker testing (galactomannan (GM), (1

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• prolonged neutropenia > 10 d, patients
• after allogeneic stem cell transplantation or solid organ transplantation,
• Patients wth acute leukemia in induction treatment,
• patients witrh graft-versus-host-disease,
• patients under chronic immunusuppressive therapy such as ciclosporin,
• patients with HIV,
• patients with chronic steroid treatment

Exclusion criteria

• Age < 18 years
• missing informed consent
• contraindication for pleural centesis

Trial design

200 participants in 2 patient groups

Immunocompromised Patients

Description:

Immunocompromised patients with suspected IPA who have Pleural effusions act as the observed study population

Control Group

Description:

Patients without Immunosuppression with pleural effusions