Diagnostic and Prognostic Value of New Biomarkers in Patients With Heart Disease

Institut National de la Santé Et de la Recherche Médicale, France

Status: Unknown

Conditions: Dyspnea; Pulmonary Disease; Heart Failure

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01374880

Unité 942 INSERM (Other Identifier)

CNIL number: 910198

Details and patient eligibility

About

The objective of this work is to investigate and then to sequence new biomarkers in the plasma of patients presenting with dyspnea secondary or not to heart failure, and study their diagnostic and prognostic value.

Full description

Plasma samples for patients with dyspnea, edema, with or without heart failure; ambulatory or admitted for cardiac decompensation (even with cardiac shock and LVAD) ; or entering a cardiac rehabilitation program, will be prospectively collected.

The objective of this work is to investigate and then to sequence new proteins in the plasma of these patients for diagnostic and prognostic purpose.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting with shortness of breath secondary or not to heart failure, even with cardiac shock and LVAD.
• Patients with valvular disease
• chronic stable heart failure.
• post- partum Cardiomyopathy

Exclusion criteria

• terminal cancer
• progressive neurological disease
• pregnancy
• opposition of the patient

Trial design

3,000 participants in 6 patient groups

Dyspnea cohort

Description:

Dyspnea cohort

Stable chronic heart failure

Description:

Stable chronic heart failure

Valvular heart disease

Description:

Valvular heart disease

Ventricular assist device

Description:

Ventricular assist device

Cardiac arrest

Description:

Cardiac arrest

Cardiac rehabilitation

Description:

Cardiac rehabilitation