Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis

University Hospital of Split

Status: Not yet enrolling

Conditions: Acute Appendicitis

Treatments: Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels

Study type: Observational

Funder types: Other

Identifiers

NCT06051825

CHCSplit

Details and patient eligibility

About

Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.

Enrollment: 100 estimated patients

Sex: All

Ages: 5 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children with age from 5 to 17 with acute abdominal pain
• children with clinical signs of appendicitis

Exclusion criteria

• previous diagnosis of chronic and/or malignant disease
• children wich had previous abdominal surgery
• pregnancy

Trial design

100 participants in 2 patient groups

Patients with acute appendicitis

Description:

Patients with acute appendicitis, after surgery and with pathohistological confirmation

Treatment:

Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels

Patients without acute appendicitis

Description:

Patients without acute appendicitis, after laboratory, clinical and/or radiological exclusion of acute admittance

Treatment:

Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels