Diagnostic Importance of the Circulating Human Leucine-rich α-2-glycoprotein in Acute Appendicitis in Pediatric Patients

KBC Split

Status: Unknown

Conditions: Appendicitis Acute

Treatments: Diagnostic Test: Saliva specimen collection; Diagnostic Test: Blood specimen collection

Study type: Observational

Funder types: Other

Identifiers

NCT05093660

2181-147/01/06/M.S.-20-02

Details and patient eligibility

About

Acute appendicitis is a common and potentially serious medical condition which can be difficult to diagnose, especially in pediatric patients. To help recognize patients with acute appendicitis, number of laboratory and radiological test are used. Previous research has shown that Circulating Human Leucine-rich α-2-glycoprotein (LGR1) in the blood can be elevated in pediatric patients with acute appendicitis. The aim of this research is to analyse whether LGR1 levels in saliva can be used as a less invasive diagnostic method in pediatric patients with suspected acute appendicitis.

Enrollment: 90 estimated patients

Sex: All

Ages: 5 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children with age from 5 do 17 with acute abdominal pain
• children with clinical signs of appendicitis

Exclusion criteria

• previous diagnosis of chronic and/or malignant disease
• children which had previous abdominal surgery
• pregnancy

Trial design

90 participants in 2 patient groups

Patients with acute appendicitis

Description:

Patients with acute appendicitis, after surgery and with pathohistological specimen confirmation.

Treatment:

Diagnostic Test: Saliva specimen collection

Diagnostic Test: Blood specimen collection

Patients without acute appendicitis

Description:

Patients without acute appendicitis, after laboratory, clinical and/or radiological exclusion of acute admittance.

Treatment:

Diagnostic Test: Saliva specimen collection

Diagnostic Test: Blood specimen collection