Diagnostic of Infections Following Major Abdominal Surgery and Burn Injury (Earlygnost)

Klinikum St. Georg gGmbH

Status: Completed

Conditions: Third Degree Burn; Second Degree Burn

Study type: Observational

Funder types: Other

Identifiers

NCT01055587

Stu09/0031

EK-BR-29/09-1

Details and patient eligibility

About

This study was designed to investigate, if new biomarkers may improve the early diagnostic of infections following major abdominal surgery and severe burn injuries.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with major abdominal surgery (e.g. gastrectomy, hemi-/colectomy, resection of sigma or rectum, resection of liver, esophagectomy)
• patients following severe burn injury (burn surface area >= 15%)
• age >= 18 years
• informed consent

Exclusion criteria

• no informed consent
• emergency surgery
• immunocompromising diseases (e.g. HIV+, AIDS, Lymphoma or NonHodgkin-Lymphoma, Autoimmune-Diseases)
• pre-existing liver or renal failure
• chronic therapy with corticoids

Trial design

120 participants in 2 patient groups

major abdominal surgery

Description:

The investigators compare the levels of biomarkers in patients with and without complications in the early postoperative course following major abdominal surgery

severe burn injury

Description:

The investigators compare levels of biomarkers within the first 20 days in patients with and without complications following severe burn injury