Diagnostic Performance of an Aspergillus-specific Nested PCR Assay in Cerebrospinal Fluid Samples

Heidelberg University

Status: Unknown

Conditions: Focus: Immunocompromised Individuals at High Risk of Aqcuiring Invasive Aspergillosis

Study type: Observational

Funder types: Other

Identifiers

NCT01614145

CSF Aspergillus PCR

Details and patient eligibility

About

Multicentre, diagnostic study evaluating the performance of an aspergillus-specific PCR in cerebrospinal fluid samples of immunocompromised patients for identification of central nervous system aspergillosis.

Enrollment: 200 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Host factors
• Informed consent

Exclusion criteria

• none

Trial design

200 participants in 2 patient groups

Proven/probable CNS IA

Description:

Immunocompromised patients with proven/probable invasive CNS Aspergillosis based on modified criteria by the EORTC/MSG

Possible/No CNS IA

Description:

Immunocompromised patients with possible/NoIA invasive CNS Aspergillosis based on modified criteria by the EORTC/MSG