Diagnostic Performance of Plasma Biomarkers of Alzheimer's Disease Compared With CSF Markers (PLASM-ALZ)

Central Hospital, Nancy, France

Status

Not yet enrolling

Conditions

Alzheimer Blood Biomarkers

Treatments

Diagnostic Test: Blood ponction

Study type

Interventional

Funder types

Other

Identifiers

NCT06304129

2023-A00709-36

Details and patient eligibility

About

.The goal of this interventional study is to estimate the diagnostic performance of plasma biomarkers of interest (Aβ40 and Aβ42, P-Tau and NFL), enabling discrimination between patients with and without a pathophysiological AD process. The main questions it aims to answer are:

to define a threshold value for each of the plasma,
to describe the correlations between the plasma biomarkers of interest and the other biological analyses performed as part of care, in particular triglyceridemia, cholesterolemia, glycemia and proteinemia,
to describe biomarker results in relation to comorbidities, in particular dyslipidemia and diabetes
to describe the final diagnosis and results obtained for plasma biomarkers, for patients with intermediate results according to the A/T/N classification (A-/T+ or A+/T-) Participants will be selected among patients undergoing lumbar puncture for the differential diagnosis of AD at Nancy University Hospital.

Enrollment

189 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Man or woman aged 18 or over
Person affiliated to a social security scheme or beneficiary of such a scheme
Person who has received full information on the organization of the research and has signed an informed consent form
Person whose care requires a lumbar puncture to measure markers of Alzheimer's disease

Exclusion criteria

Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
An adult unable to give consent
Persons deprived of their liberty by judicial or administrative decision
Persons under psychiatric care under articles L. 3212-1 and L. 3213-1.
Pregnant, parturient or breast-feeding women
Persons staying in a health or social establishment for purposes other than research.