Diagnostic Performance of Plasma Procalcitonin for the Detection of Blood Cultures Contaminations

Central Hospital, Nancy, France

Status: Completed

Conditions: Blood Culture Contamination; Bacteremia; Contamination

Treatments: Diagnostic Test: Procalcitonin dosage

Study type: Observational

Funder types: Other

Identifiers

NCT04573894

2020PI140

Details and patient eligibility

About

In blood cultures, species considered as potentially contaminating (coagulase negative staphylococci (CNS), Bacillus spp., Corynebacterium spp., Cutibacterium acnes, Micrococcus spp., viridans group streptococci, and Clostridium perfringens) can, however, be responsable for true bacteremia.

Blood levels of the prohormone procalcitonin (PCT) markedly increase in the early stages of bacterial infections. The aim of our study is to determine the role of plasma PCT as a biomarker differentiating blood culture contaminations from true bacteremia.

Full description

Blood culture contamination is defined by the introduction into of a microorganism into blood culture bottles from either the patient's or healthcare worker's flora, or the immediate environment during specimen collection. Species considered as potentially contaminating (coagulase negative staphylococci (CNS), Bacillus spp., Corynebacterium spp., Cutibacterium acnes, Micrococcus spp., viridans group streptococci, and Clostridium perfringens) can, however, be responsible for true bacteremia. If an organism belonging to one of those species is detected in isolates, rapidly and accurately assessing its contaminant or infectious potential is hence important to ensure effective antibiotic therapy as well as to reduce financial burden caused by unnecessary treatments, and additional clinical and laboratory costs.

Blood levels of the prohormone procalcitonin (PCT) markedly increase in the early stages of bacterial infections. The aim of our study is to determine the role of plasma PCT as a biomarker differentiating blood culture contaminations from true bacteremia.

Enrollment: 147 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least one blood culture positive for of the following microorganisms: coagulase negative staphylococci, viridans group streptococci
• PCT levels measurement on the day of blood culture specimen collection
• Adult patients

Exclusion criteria

• Patients with less than 3 blood culture bottles collected

Trial design

147 participants in 1 patient group

Positives blood cultures

Description:

Collection of clinical and biological data of patients with blood cultures positives for potential contaminants, as well as PCT levels measurements, from January 2016 to May 2019 at the Nancy CHRU

Treatment:

Diagnostic Test: Procalcitonin dosage