Diagnostic Performance of the Resistance Index (RI) for the Assessment of Cerebral Vasoreactivity in Transcranial Doppler (REVACEIR)

Centre Hospitalier Universitaire de Nīmes

Status

Enrolling

Conditions

Occlusion

Stenosis

Treatments

Diagnostic Test: Transcranial Doppler

Study type

Observational

Funder types

Other

Identifiers

NCT05780619

NIMAO/2022/SC-01

Details and patient eligibility

About

Routine revascularization of asymptomatic carotid stenosis is questionable as optimal medical therapy has significantly reduced the risk of stroke. Therefore, it is crucial to identify high-risk patients who may still benefit from carotid revascularization. In 2017, the ESC guidelines clarified the criteria associated with a high risk of stroke despite optimal treatment to consider a revascularization procedure, including altered cerebral vasoreactivity. However, cerebral vasoreactivity using transcranial Doppler ultrasound is reserved for qualified centers. It requires a technical platform and trained personnel, is time-consuming and generally not readily available.

A simpler test is therefore necessary. The goal is to quickly and easily detect patients with normal vasoreactivity who do not benefit from the cerebral vasoreactivity test (reference standard) and to reserve the time-consuming cerebral vasoreactivity test for patients likely to have altered vasoreactivity.

The hypothesis of the study is that on a routine measure in transcranial echo-Doppler, the resistance index (RI), can predict the response to the cerebral vasoreactivity test. With this new test, it will be possible to select patients who do not benefit from pharmacological cerebral vasoreactivity testing ("true negatives"). Thus, the time-consuming cerebral vasoreactivity test will be reserved only for patients with a possibility of impaired vasoreactivity.

Enrollment

77 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The patient must have given their free and informed consent and signed the consent form
The patient must be a member or beneficiary of a health insurance plan
Stenosis ≥ 70% in diameter reduction in NASCET equivalent or occlusion of atheromatous origin of the cervical internal carotid artery, asymptomatic or symptomatic.
Presence of a temporal window sufficient to record the homolateral and contralateral middle cerebral artery.
Patient of legal age with free and informed consent.
Patient who has signed the consent form.
Patient affiliated or beneficiary of a health insurance plan.

Exclusion criteria

The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
The subject refuses to sign the consent
It is impossible to give the subject informed information
The patient is under safeguard of justice or state guardianship
Contraindication to Acetazolamide Diamox® injection.
Absence of temporal acoustic window (non visualization of the cerebral parenchyma, no recordable intracranial vessel).
Insufficient temporal window (visualizable brain parenchyma, no recordable MCA)
Internal or common carotid artery stenosis ≥70% or occlusion, contralateral to the primary lesion.
Stenosis ≥50% of the middle cerebral artery homolateral or contralateral to the cervical lesion.
Patient in exclusion period determined by another study.
Patient under court protection, guardianship, or conservatorship.
Patient refusing to sign the consent form.
Patient unable to express his or her will (dementia, disturbed consciousness, etc.)
Patient for whom it is impossible to give informed information for health reasons or because of a language barrier.
Pregnant, parturient, or breastfeeding patient.