Diagnostic Reliability of OCT Biomarkers for iERM

Vienna Institute for Research in Ocular Surgery

Status: Completed

Conditions: Idiopathic Epiretinal Membranes

Treatments: Other: Biomarker analysis

Study type: Observational

Funder types: Other

Identifiers

NCT04997876

biomarkers

Details and patient eligibility

About

Several optical coherence tomography (OCT) biomarkers with potential to influence postsurgical outcomes after vitrectomy with membrane peeling for idiopathic epiretinal membranes (iERM) have been described in single predictor analyses in the past. Aim of the study is to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity in a multiple regression analysis.

Full description

Several optical coherence tomography (OCT) biomarkers with potential to influence postsurgical outcomes after vitrectomy with membrane peeling for idiopathic epiretinal membranes (iERM) have been described in single predictor analyses in the past. A recent multifactorial analysis outlined macular thickness and DRIL to be significant predictors for postsurgical visual acuity (Karasavviodou et al.). Nevertheless, reliability of diagnosing OCT biomarkes among patients with iERM was not yet assessed, to our knowledge. Aim of the study is to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity in a multiple regression analysis.

Enrollment: 136 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• a) presence of an iERM,
• b) indication for membrane peeling, defined as significant loss of visual acuity and/or metamorphopsia due to the ERM,
• c) pseudophakia at the final visit at 3 months after surgery, and
• d) written informed consent for study participation.

Exclusion criteria

• macular edema caused by conditions other than ERM were excluded from the study.

Trial design

136 participants in 1 patient group

Study Group

Description:

Biomarkers from presurgical OCTs are diagnosed

Treatment:

Other: Biomarker analysis