Diagnostic Value of CircRNA-Uck2 for Acute Myocardial Infarction

Beijing Haidian Hospital

Status: Unknown

Conditions: Cardiac Disease; Diagnoses Disease; Acute Myocardial Infarction

Treatments: Diagnostic Test: the diagnosis value of cUck2 in acute myocardial infarction.

Study type: Interventional

Funder types: Other

Identifiers

NCT03170830

KYZ2017001

Details and patient eligibility

About

This is an observational diagnostic study that aims to evaluate the diagnostic value of circRNA-Uck2 in Acute Myocardial Infarction (AMI) in adults as compared to healthy and unstable angina controls. Rapid and adequate diagnosis of AMI is of great importance to enable a rapid start of treatment, save large tracts of dying myocardium, reduce the infarct size,and thereby decrease the risk of subsequent heart failure.

Full description

RATIONAL acute myocardial infarction (AMI) is the leading cause of sudden death and heart failure worldwide. And about 10% of all emergency department consultations are with symptoms suggestive of AMI, however, only 10% to 20% of them are diagnosed as experiencing an AMI. Rapid and accurate identification of AMI is of paramount clinical importance for subsequent timely and effectively treatment and management.

Recently, the investigators identified microarray analysis and real-time polymerase chain reaction (PCR) from AMI animal models and small samples of AMI patients, a molecular signature of AMI involving 5 circRNAs (circRNA_006877, circRNA_015350, circRNA_002969, circRNA_013240, circRNA_004682) was found significantly change in AMI patients and likely serves as candidate serum biomarkers of AMI. Among the 5 circRNAs, circRNA_006877 name of circRNA-Uck2 (cUck2) has more close association with AMI.

TYPE OF STUDY : multicenter diagnostic evaluation Study MAIN PURPOSE OF THE STUDY : To evaluate the diagnostic value of circRNAs in AMI in adults as compared to healthy and unstable angina controls

SECONDARY OBJECTIVES :

assess the ability of cUck2 to discriminate a AMI disease from unstable angina patients in adults.

explore the relationship between cUck2 and heart function after myocardial infarction PRODUCTS OF THE STUDY diagnostic kit of AMI in quantitative polymerase chain reaction (qPCR) NUMBER OF PATIENTS : 3 groups with 169 patients will be included Group 1: 66 AMI adult patients Group 2: 56 unstable angina adults Group 3: 56 Witnesses healthy adults INCLUSION LENGTH 36 months DURATION OF THE STUDY 42 months

Enrollment: 178 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Health Control Group:Pepole who have normal ECG, deny the history of cardiovascular disease can be included in the healthy control group.
• Acute Myocardial Infarction Group:Clinical diagnosis of acute myocardial infarction
• Unstable Angina Group:Clinical diagnosis of unstable angina.
• Sign informed consent.

Exclusion criteria

• Myocarditis, hypertrophic cardiomyopathy, ablation.
• Malignant hypertension, severe arrhythmia.
• Chronic muscle disorders, rhabdomyolysis.
• Severe liver and kidney dysfunction.
• Malignant tumors, acute cerebrovascular disease.
• Severe neurosis, psychosis.
• Patients who had any of the above were excluded.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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178 participants in 3 patient groups

Healthy control group

Experimental group

Description:

Age:45-75 years.Pepole who have normal ECG without the history of cardiovascular disease can be included in the healthy control group.

Treatment:

Diagnostic Test: the diagnosis value of cUck2 in acute myocardial infarction.

unstable angina disease control group

Experimental group

Description:

Age:\>18 years.Unstable angina patients meet the diagnostic criteria.

Treatment:

Diagnostic Test: the diagnosis value of cUck2 in acute myocardial infarction.

acute myocardial infarction group

Experimental group

Description:

Age:\>18 years.Acute myocardial infarction patients meet the diagnostic criteria.

Treatment:

Diagnostic Test: the diagnosis value of cUck2 in acute myocardial infarction.