Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection

Republic of Turkey Ministry of Health

Status: Enrolling

Conditions: Pulmonary Embolism; Aortic Dissection

Treatments: Diagnostic Test: D-dimer/fibrinogen ratio

Study type: Observational

Funder types: Other

Identifiers

NCT04251247

2020/514/169/B

Details and patient eligibility

About

Acute aortic dissection is rare but potentially life-threatening disease with an incidence of 5-30 cases per million, annually. Therefore prompt diagnosis is crucial. D-dimer values have been shown to be useful in the diagnosis of acute aortic dissection. Fibrinogen levels have been shown to be low, normal or high in individuals with acute aortic dissection. This study aims to investigate whether D-dimer/fibrinogen ratio can be valuable for diagnosis of acute aortic dissection.

Enrollment: 159 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of acute aortic dissection
• Diagnosis of acute pulmonary embolism
• Diagnosis of non-cardiac chest pain

Exclusion criteria

• Any etiology of chest pain other than acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain
• Participants who do not give consent for enrollment

Trial design

159 participants in 3 patient groups

Acute aortic dissection

Description:

Patients with a diagnosis of acute aortic dissection.

Treatment:

Diagnostic Test: D-dimer/fibrinogen ratio

Acute pulmonary embolism

Description:

Patients with a diagnosis of acute pulmonary embolism

Treatment:

Diagnostic Test: D-dimer/fibrinogen ratio

Non-cardiac chest pain

Description:

Patients with non-cardiac chest pain

Treatment:

Diagnostic Test: D-dimer/fibrinogen ratio