Diagnostic Value of Transbronchial Lung Cryobiopsy

Catholic University (KU) of Leuven

Status: Unknown

Conditions: Interstitial Lung Disease

Treatments: Procedure: transbronchial lung cryobiopsy

Study type: Observational

Funder types: Other

Identifiers

NCT02579304

UZLPNE1015

Details and patient eligibility

About

Evaluating the diagnostic value of transbronchial lung cryobiopsy (TBLC) as well as its procedural feasibility and safety in a prospective series of 20 patients with diffuse interstitial lung diseases (DILD) who are referred for invasive histopathological diagnostics

Full description

Before one is able to state that TBLC is a technique that is an alternative for VATS biopsy, the diagnostic value of TBLC should be assessed and the value of the histopathological sampling should be compared with what is achieved by surgical lung biopsy. For this purpose direct comparison between VATS biopsy and TBLC is unavoidable. By including TBLC in the work-up of patients with DILD in which histopathological assessment is indicated (as proposed by MDD), we want to assess 3 major points of concern.

Agreement for the histopathological diagnosis between VATS biopsy and TBLC. Value of TBLC in the specific diagnosis in ILD.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Case of DILD presented at the MDD
• Referral for VATS biopsy as advised by MDD.
• Informed consent available
• Age > 18
• FVC > 50%pred
• DLCO > 40%pred
• PaO2 > 65 mmHg, pCO2 < 45 mmHg
• No exclusion criteria

Exclusion criteria

• • Age > 75
• PAPS >40mmHg as measured on transthoracic cardiac ultrasound
• Platelet count <100000/µl
• INR > 1.4
• BMI >30
• Diffuse bullous lung disease
• Active anti-platelet or anticoagulant treatment
• Active heart failure or unstable coronary heart disease
• Patients unfit for VATS under general anaesthesia as assessed by the surgeon and/or anesthesiologist