Diaphragm Structure and Function in Childhood Cancer Survivors
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Treatments
Details and patient eligibility
About
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.
Full description
During the first study visit, participants will undergo a series of pulmonary function and muscle performance tests followed by treadmill walking trials at different speeds with concurrent expired gas analysis via a face mask. The participants will then perform a training program for the breathing muscles at home for 6 weeks. The research team will follow up each week via telehealth visits to support training. After the 6-week training program, participants will return in-person for a follow-up visit and will undergo the same series of assessments as the first visit.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Completed medical treatment (chemotherapy, chemotherapy/surgery, chemotherapy/radiation or any combination of cancer treatment) for any type of cancer, except for cancer of the central nervous system, at least 1 year ago
Exclusion criteria
- History of neuromuscular, cardiac, or pulmonary disease prior to the diagnosis of cancer
- Recent injury or condition (less than 6 months ago) that precludes strength testing or walking
- Dyspnea with minimal activity (4 on the modified Medical Research Council Dyspnea Scale)
Trial design
Primary purpose
Allocation
Interventional model
Masking
13 participants in 1 patient group
Trial contacts and locations
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Central trial contact
Martina Miller
Data sourced from clinicaltrials.gov
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