Diaphragm Thickness by Ultrasonography in Neurological Disorders

M

Mansoura University

Status

Completed

Conditions

Myasthenia Gravis
Guillain-Barre Syndrome

Treatments

Radiation: diaphragmatic ultrasound

Study type

Interventional

Funder types

Other

Identifiers

NCT05324176
MD.19.06.186.R1.R2

Details and patient eligibility

About

participants will be allocated into three groups, acute neuropathy (Guillain Barre Syndrome) group, neuromuscular junction disorder(myasthenia gravis ) group, and control group(people with neurological disorders not affecting the respiratory system.Ultrasonography is done on the diaphragm. The index test (ultrasound imaging of the diaphragm) is used. A high-resolution portable ultrasound machine is used, with a 7- to 13-MHz linear array transducer. Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration. objectives: primary outcome: to compare diaphragm thickness between the three examined groups. Secondary outcome: correlation between clinical scores and reference US values of diaphragm

Full description

after IRB (institutional research board ) approval, of the faculty of medicine, Mansoura University, Egypt, written informed consent from all participants will be taken. participants will be allocated into three groups, acute neuropathy (Guillain Barre Syndrome) group, neuromuscular junction disorder(myasthenia gravis ) group, and control group(people with neurological disorders not affecting the respiratory system. inclusion group: age more than 18, both sexes. exclusion criteria: cardiopulmonary disease, chest trauma, diaphragmatic injury, body mass index more than 30. Any participant who shows respiratory dysfunction on doing arterial blood gases and pulmonary function tests will not be enrolled in the study. methods: Ultrasonography is done on the diaphragm. The index test (ultrasound imaging of the diaphragm) is used. A high-resolution portable ultrasound machine is used, with a 7- to 13-MHz linear array transducer. Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration. objectives: primary outcome: to compare diaphragm thickness between the three examined groups. Secondary outcome: correlation between clinical scores and reference US values of diaphragm

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • all adult patients admitted to the neurology department

Exclusion criteria

  • cardiopulmonary diseases
  • chest trauma
  • diaphragmatic diseases
  • Body Mass Index (BMI) > 30

Trial design

Primary purpose

Screening

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

60 participants in 3 patient groups

Gillian-Barre
Active Comparator group
Description:
Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration.
Treatment:
Radiation: diaphragmatic ultrasound
Myasthenia Gravis
Active Comparator group
Description:
Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration.
Treatment:
Radiation: diaphragmatic ultrasound
control
Active Comparator group
Description:
Patients hospitalized with neurological disorders without affection of the respiratory system.
Treatment:
Radiation: diaphragmatic ultrasound

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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