Diaphragm Ultrasound in Neuromuscular Disorders

Centre d'Investigation Clinique et Technologique 805

Status: Unknown

Conditions: Muscular Dystrophies

Study type: Observational

Funder types: Other

Identifiers

NCT04045158

DIAPH-NMD

Details and patient eligibility

About

Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function.

The aims of the study are:

• to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies
• to assess the correlation between diaphragm ultrasound and FPT
• to assess the correlation between diaphragm ultrasound and cardiac function

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Duchenne muscular dystrophy,
• Becker muscular dystrophy,
• LGMD,
• myotonic dystrophy type 1 and type 2,
• metabolic myopathy,
• mitochondrial myopathy,
• FSHD1 and 2,
• myasthenia

Exclusion criteria

• history of cardiac surgery
• history of thoracic surgery
• brain traumatism