Diaphragmatic Ultrasound and Thoracic Fluid Content for Prediction of Non-Invasive Ventilation Failure in Neonates

Lamiaa Khaled Zidan

Status: Completed

Conditions: RDS of Prematurity; Non Invasive Ventilation (NIV); Diaphragm Ultrasound; Electrical Cardiometry

Treatments: Device: Diaphragmatic US; Device: EC

Study type: Observational

Funder types: Other

Identifiers

NCT07148102

DTF, DE, TFC with NIV failure

Details and patient eligibility

About

This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.

Full description

Non-invasive ventilatory support (NIV) is considered a gold standard care for preterm infants with respiratory distress syndrome (RDS); however, NIV failure remains a frequent challenge that is often associated with many adverse outcomes

Enrollment: 90 patients

Sex: All

Ages: 30 to 30 minutes old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Preterm neonates of both sexes, with gestational ages ranging from 28 to 34 weeks, diagnosed with RDS and requiring non-invasive ventilation within 30 minutes of birth

Exclusion criteria

• Exclusion criteria included intubation in the delivery room, complex congenital heart disease, major congenital anomalies in the lungs or airways, and other causes of respiratory distress unrelated to RDS.

Trial design

90 participants in 3 patient groups

CPAP

Description:

30 infants supported by nasal CPAP

Treatment:

Device: EC

Device: Diaphragmatic US

NIPPV

Description:

30 infants supported by non-invasive positive pressure ventilation

Treatment:

Device: EC

Device: Diaphragmatic US

NHFOV

Description:

30 infants supported with nasal high-frequency oscillatory ventilation

Treatment:

Device: EC

Device: Diaphragmatic US