Diastolic Blood Pressure and Lipid Profile in Infants (ERAhmed)

Assiut University

Status: Unknown

Conditions: Breastfeeding, Exclusive

Treatments: Dietary Supplement: S. Cholesterol S. Triglyceride

Study type: Observational

Funder types: Other

Identifiers

NCT03612427

ERAhmed AssiutU

Details and patient eligibility

About

The influence of early environmental factors, including nutrition, on future cardiovascular disease (CVD) risk and, in a broader view, the concept of early metabolic programming and future health have been extensively discussed during the past decades. Observational studies have suggested that formula-fed infants as compared with breastfed infants have an elevated risk of future CVD.

Full description

The influence of early environmental factors, including nutrition, on future cardiovascular disease (CVD) risk and, in a broader view, the concept of early metabolic programming and future health have been extensively discussed during the past decades. Observational studies have suggested that formula-fed infants as compared with breastfed infants have an elevated risk of future CVD, since they have faster early growth rate and higher risk of overweight, type 2 diabetes, high blood pressure, and unfavorable blood lipid profile in adult age. Formula-fed preterm infants have higher serum C-reactive protein (CRP) concentration, higher serum low-density lipoprotein to high-density lipoprotein (LDL:HDL) ratio, and higher serum apolipoprotein B to apolipoprotein A1 (apoB:apoA1) ratio in adolescence as compared with preterm infants receiving banked breast milk.

Enrollment: 120 estimated patients

Sex: All

Ages: 10 to 14 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Breastfed infants

2. Formula-fed infants

3. Raw milk fed infants

4. Mixed fed infants

   1. Breast milk plus raw milk
   2. Breast milk plus formula

Exclusion criteria

1. Children with Cong. Heart Disease, family history of congenital hyperlipidemia and cases which prove hyperlipidemia of high levels (congenital).

Trial design

120 participants in 2 patient groups

Breastfed infants

Description:

Infants depending on breastfeeding S. Cholesterol S. Triglycerides S. HDL Cholesterol

Treatment:

Dietary Supplement: S. Cholesterol S. Triglyceride

Formula-fed infants

Description:

Infants have formula feeding S. Cholesterol S. Triglycerides S. HDL Cholesterol

Treatment:

Dietary Supplement: S. Cholesterol S. Triglyceride