Diastolic Dysfunction and Atrial Fibrillation in CABG Surgery

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University Health Network, Toronto

Status

Completed

Conditions

Atrial Fibrillation
Heart Disease

Treatments

Procedure: Diastolic measurements during TEE

Study type

Observational

Funder types

Other

Identifiers

NCT00188903
UHN REB 03-0873-A

Details and patient eligibility

About

Left ventricular (LV) diastolic dysfunction is a common manifestation of heart disease that is responsible for significant morbidity and mortality.It is present when the ventricular filling is impaired as a result of delayed relaxation or decreased compliance. During Coronary artery bypass grafting (CABG) surgery, LV diastolic dysfunction is a frequent occurrence. Failure of the left ventricle to dilate normally causes an increase in LV filling pressure. Atrial fibrillation (AF) is a common complication after cardiac surgery affecting 20-30% of patients undergoing coronary revascularization procedures. AF is associated with significant morbidity and mortality and has been identified as a causative factor of increased length of both hospital and intensive care unit (ICU) stay after CABG surgery, resulting in increased resource utilization and medical care costs.The primary aim of this study is to determine if patients with preoperative diastolic dysfunction are exposed to higher risk of AF after coronary revascularization surgery.

Enrollment

250 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • scheduled for elective CABG or OPCAB surgery
  • signed informed consent

Exclusion criteria

  • Patients with a history of previous heart surgery and/or undergoing valvular heart surgery.
  • Patients with preoperative atrial fibrillation.
  • Patients in whom TEE is contraindicated.

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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