Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Lung Edema; Diastolic Dysfunction; Fluid Overload; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT03768752

DD-Sepsis

Details and patient eligibility

About

Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality. However, the reasons for this remain unclear. Therefore, the goal of this study is to investigate diastolic dysfunction in septic patients on the intensive care unit. Special attention is paid to the presence of lung edema and general edema as a potential link between diastolic dysfunction and elevated mortality in septic patients. During the septic phase daily ultrasound examinations of heart and lung will be performed as to monitor diastolic function and lung edema.

Enrollment: 83 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients on the intensive care unit diagnosed with SIRS (systemic inflammatory response syndrome) or Sepsis.

Exclusion criteria

• Patients with hemodynamically relevant cardiac defects.
• Patients with mitral valve replacement.
• Patients with pericardial effusion.
• Patients with atrial fibrillation.
• Patients with pacemaker therapy.
• Patients with BMI > 35 kg/m2.
• Patients with poor examination conditions for ultrasound.

Trial design

83 participants in 2 patient groups

Diastolic Dysfunction

Description:

Patients with pre-existing or new diastolic dysfunction.

Normal Diastolic Function

Description:

Patients with normal diastolic function.