Diazepam and Blood Pressure Regulation

University of Brasilia

Status and phase: Completed; Early Phase 1

Conditions: Healthy

Treatments: Drug: Diazepam

Study type: Interventional

Funder types: Other

Identifiers

NCT05069779

70101717.1.0000.5103

Details and patient eligibility

About

The aim of this study is to determine the acute effects of diazepam on beat-to-beat blood pressure variability and baroreflex control.

Full description

Benzodiazepines are widely prescribed for a variety of clinical conditions. However, its cardiovascular consequences remain controversial. In this study, the investigators sought to determine the acute effects of a single dose of oral diazepam (10mg) on resting beat-to-beat blood pressure variability and cardiac and sympathetic baroreflex sensitivity in a cohort of young, healthy individuals.

Enrollment: 40 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 40 years of age
• Healthy, free of known cardiovascular, metabolic, or musculoskeletal disease

Exclusion criteria

• History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months
• Diagnosed cardiovascular or metabolic disease(s)
• Prescription of chronic medications other than oral contraceptives
• History of hypertension or presence of arrhythmia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

Diazepam

Experimental group

Description:

Oral

Treatment:

Drug: Diazepam

Placebo

Placebo Comparator group

Description:

Oral

Treatment:

Drug: Diazepam