Dibenzyl Trisulphide (GUINEAHEN WEED) for Stage IV Cancer

The University of The West Indies

Status and phase: Unknown; Early Phase 1

Conditions: Stage IV Prostate Cancer; Stage IV Colon Cancer; Stage IV Cancer of the Cervix; Stage IV Breast Cancer

Treatments: Drug: Stage IV: Colon Cancer Placebo; Drug: Stage IV Breast Cancer Placebo; Drug: Cervical Cancer Stage IV Placebo; Drug: Dibenzyl trisulphide capsules; Drug: Cancer of the Prostate Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04113096

ECP 250 - 15/16

Details and patient eligibility

About

This study is being done to find the effect of Dibenzyl Trisulphide (active ingredient in Guinea Hen Weed in combination in patients with stage four cancer of the breast, prostate, cervix and colon.

Full description

There have been many claims of the value of Guinea Hen weed in the treatment of different cancers. The preparation is readily available and used locally. The team proposes to validate the studies done on cancer cell lines by conducting a clinical trial to determine the clinical benefit in advanced and metastatic cancers.

Enrollment: 104 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Age: Greater than 12 years.

• Documented histologic evidence of cancer

• Staged as stage IV

• World Health Organization (WHO) Performance Status of between 0 and 2

• Radiological confirmation of metastases with bone scan or X ray, CT and/or MRI scan Exclusion Criteria

  • Cancer stages less than stage 4
  • Pregnant women
  • Children 0 - 12 years

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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104 participants in 4 patient groups

Breast Cancer Stage IV

Experimental group

Description:

Stage IV Breast Cancer: Dibenzyl trisulphide capsules (20mg once daily)/6 months

Treatment:

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Drug: Stage IV Breast Cancer Placebo

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Colon Cancer Stage IV

Experimental group

Description:

Stage IV Colon Cancer:Dibenzyl trisulphide capsules (20 mg one daily for 6 months

Treatment:

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Drug: Stage IV: Colon Cancer Placebo

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Cervical Cancer Stage IV

Experimental group

Description:

Stage IV Cancer of the Cervix: Dibenzyl trisulphide capsules (20 mg once daily) for 6 months

Treatment:

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Drug: Cervical Cancer Stage IV Placebo

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Cancer of the Prostate Stage IV

Experimental group

Description:

Stage IV Prostate cancer:Dibenzyl trisulphide capsules (20 mg once daily) for 6 months

Treatment:

Drug: Cancer of the Prostate Placebo

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules

Drug: Dibenzyl trisulphide capsules