DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study (DIC-ECMO)

Queen Mary Hospital

Status: Enrolling

Conditions: Extracorporeal Membrane Oxygenation Complication; Extracorporeal Circulation; Complications

Treatments: Diagnostic Test: DIC markers and Thrombin Generation Parameters

Study type: Observational

Funder types: Other

Identifiers

NCT06095518

UW 23-259

Details and patient eligibility

About

To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.

Enrollment: 50 estimated patients

Sex: All

Ages: Under 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≧ 18; AND
• Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital or Tuen Mun Hospital in Hong Kong; AND
• Require either veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support.

Exclusion criteria

• Patients who are on central VA-ECMO support; OR
• Patients with missing clinical data; OR
• Patients with pre-existing thromboembolism requiring long term anticoagulation prior to ECMO cannulation; OR
• Post-operative admissions

Trial design

50 participants in 2 patient groups

Adult Intensive Care Unit, Queen Mary Hospital

Treatment:

Diagnostic Test: DIC markers and Thrombin Generation Parameters

Department of Intensive Care Unit, Tuen Mun Hospital

Treatment:

Diagnostic Test: DIC markers and Thrombin Generation Parameters