Dichloroacetate Kinetics, Metabolism and Toxicology

National Institutes of Health (NIH)

Status: Completed

Conditions: Lactic Acidosis

Treatments: Drug: Dichloroacetate

Study type: Observational

Funder types: NIH

Identifiers

NCT00015015

7355-CP-001

Details and patient eligibility

About

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Sex: All

Ages: 3 months to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Children with congenital lactic acidosis Healthy adult volunteers